EGF binding triggers dimerization of the receptor and promotes autophosphorylation. The activate receptor dimer binds one EGF molecule. Heterodimer with ERBB2. Interacts with ERRFI1. Interaction with ERRFI1 inhibits dimerization of the kinase domain and autophosphorylation. Binds RIPK1. Interacts (via autophosphorylated C-terminal tail) with CBL. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. Interacts (autophosphorylated form) with PIK3C2B; the interaction may be indirect. Interacts with PELP1. Binds MUC1. Interacts with AP2M1. Interacts with GAB2. Interacts with COPG, upon EGF treatment; interaction is essential for regulation of EGF-dependent nuclear transport of EGFR by retrograde trafficking from the Golgi to the ER. Interacts with TNK2; this interaction is dependent on EGF stimulation and kinase activity of EGFR. Interacts with FER.
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Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2)
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Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 3 AND 4)
"Cloning of the cDNA for a short EGF receptor from human placenta." Xu L.
,
Hong A.
,
He X.
Submitted (2004-07) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
7.
NIEHS SNPs program
Submitted (2004-04) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS GLN-98; ARG-266; LYS-521; ILE-674; GLY-962 AND PRO-988
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Cited for: PROTEIN SEQUENCE OF 687-705; 986-998; 1000-1023; 1026-1030 AND 1068-1077;PHOSPHORYLATION AT THR-693; SER-695; SER-1070 AND SER-1071
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Cited for: PROTEIN SEQUENCE OF 861-875 AND 914-932;UBIQUITINATION AT LYS-716; LYS-737; LYS-754; LYS-867; LYS-929 AND LYS-970;IDENTIFICATION BY MASS SPECTROMETRY
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Cited for: FUNCTION IN PHOSPHORYLATION OF CBL;INTERACTION WITH CBL
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Cited for: GLYCOSYLATION AT ASN-128; ASN-175; ASN-413; ASN-444 AND ASN-528
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Cited for: PHOSPHORYLATION;DEPHOSPHORYLATION BY PTPN1 AND PTPN2
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Cited for: GLYCOSYLATION AT ASN-56; ASN-352; ASN-361; ASN-568 AND ASN-603
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Cited for: GLYCOSYLATION AT ASN-56; ASN-128; ASN-175; ASN-196; ASN-352; ASN-361; ASN-413; ASN-444; ASN-528; ASN-568; ASN-603 AND ASN-623
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Cited for: FUNCTION IN CELL PROLIFERATION;INTERACTION WITH STAT3;PHOSPHORYLATION AT TYR-1092 AND TYR-1110
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Cited for: FUNCTION IN EGFR SIGNALING;IDENTIFICATION IN A COMPLEX WITH PIK3C2A AND ERBB2;IDENTIFICATION IN A COMPLEX WITH PIK3C2B AND ERBB2;INTERACTION WITH PIK3C2B;MUTAGENESIS OF TYR-1016; TYR-1092; TYR-1110; TYR-1172 AND TYR-1197
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Cited for: FUNCTION IN NF-KAPPA-B ACTIVATION;INTERACTION WITH RIPK1
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Cited for: FUNCTION IN PHOSPHORYLATION OF MUC1;INTERACTION WITH MUC1
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Cited for: GLYCOSYLATION AT ASN-56; ASN-128; ASN-175; ASN-196; ASN-352; ASN-361; ASN-413; ASN-444; ASN-528; ASN-568 AND ASN-603;PHOSPHORYLATION AT THR-693; SER-991 AND SER-1026;IDENTIFICATION BY MASS SPECTROMETRY
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1172 AND TYR-1197;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: FUNCTION IN CELL PROLIFERATION;FUNCTION IN PCNA PHOSPHORYLATION;INTERACTION WITH PCNA;SUBCELLULAR LOCATION
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-693; SER-695; SER-1064; SER-1081; SER-1166 AND TYR-1197;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-991; SER-995; TYR-998; SER-1039; THR-1041; SER-1042; SER-1064 AND SER-1166;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: ENZYME REGULATION BY PTPRJ AND PTPRK;PHOSPHORYLATION AT TYR-1197;DEPHOSPHORYLATION BY PTPRJ;SUBCELLULAR LOCATION;INTERACTION WITH CBL AND GRB2
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Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-352; ASN-413 AND ASN-568
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: INTERACTION WITH COPG1;SUBCELLULAR LOCATION;TOPOLOGY
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-693; SER-991; SER-1064 AND TYR-1197;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: FUNCTION IN CELL PROLIFERATION AND CELL MIGRATION;METHYLATION AT ARG-1199 BY PRMT5;INTERACTION WITH PRMT5 AND PTPN6
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Cited for: INTERACTION WITH ANKRD13A; ANKRD13B AND ALKRD13D;UBIQUITINATION;SUBCELLULAR LOCATION
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Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 25-646 IN COMPLEX WITH EGF;FUNCTION IN MAPK1 AND/OR MAPK3 ACTIVATION;SUBUNIT;SUBCELLULAR LOCATION;MUTAGENESIS OF TYR-275; PHE-287; ARG-309 AND ARG-429;DISULFIDE BONDS;GLYCOSYLATION AT ASN-56; ASN-175; ASN-196; ASN-352; ASN-361 AND ASN-444
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Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 25-642 IN COMPLEX WITH EGF;FUNCTION;SUBUNIT;MUTAGENESIS OF 587-ASP--HIS-590 AND LYS-609;DISULFIDE BONDS;GLYCOSYLATION AT ASN-352; ASN-361; ASN-444; ASN-528; ASN-568 AND ASN-603
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Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 695-1022 IN COMPLEX WITH GW572016;CATALYTIC ACTIVITY;FUNCTION
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Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 25-642 IN COMPLEX WITH CETUXIMAB
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Cited for: X-RAY CRYSTALLOGRAPHY (2.47 ANGSTROMS) OF 696-1022 OF WILD-TYPE AND VARIANTS SER-719 AND ARG-858 IN COMPLEXES WITH ATP ANALOGS AND SYNTHETIC INHIBITORS;CATALYTIC ACTIVITY;AUTOPHOSPHORYLATION;CHARACTERIZATION OF VARIANTS SER-719 AND ARG-858
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Cited for: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) OF 702-1022 IN COMPLEX WITH ERRFI1;ENZYME REGULATION;CATALYTIC ACTIVITY;AUTOPHOSPHORYLATION;SUBUNIT;INTERACTION WITH ERRFI1
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Cited for: X-RAY CRYSTALLOGRAPHY (3.05 ANGSTROMS) OF 695-1022 OF VARIANT MET-790;CATALYTIC ACTIVITY;CHARACTERIZATION OF VARIANT MET-790
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Cited for: X-RAY CRYSTALLOGRAPHY (2.96 ANGSTROMS) OF 696-1022;CATALYTIC ACTIVITY;PHOSPHORYLATION AT TYR-998; TYR-1016 AND TYR-1197;MUTAGENESIS OF LEU-688; GLU-690; LEU-692; ARG-977 AND 1005-GLU-ASP-1006;SUBUNIT
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Cited for: X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 669-1022 OF MUTANT MET-745;CATALYTIC ACTIVITY;FUNCTION;SUBUNIT;SUBCELLULAR LOCATION;AUTOPHOSPHORYLATION;MUTAGENESIS OF LEU-688; VAL-689; GLU-690; LEU-692; THR-693; PRO-694; PRO-699; ASN-700; LEU-704; ARG-705; ILE-706 AND LYS-745
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Cited for: STRUCTURE BY NMR OF 634-677 IN COMPLEX WITH ERBB2;SUBUNIT
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Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 25-638 IN COMPLEX WITH EGF;FUNCTION;SUBUNIT;DISULFIDE BONDS;GLYCOSYLATION AT ASN-56; ASN-73; ASN-175; ASN-196; ASN-352; ASN-361; ASN-444 AND ASN-528
86.
"Crystal structure of Cbl-b TKB domain in complex with EGFR pY1069 peptide." Structural genomics consortium
Submitted (2010-10) to the PDB data bank
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Cited for: X-RAY CRYSTALLOGRAPHY (2.27 ANGSTROMS) OF 1066-1076 IN COMPLEX WITH CBLB;INTERACTION WITH CBLB
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Cited for: X-RAY CRYSTALLOGRAPHY (1.52 ANGSTROMS) OF 1062-1074 IN COMPLEX WITH CBLC;PHOSPHORYLATION AT TYR-1069;INTERACTION WITH CBLC;MUTAGENESIS OF GLN-1067; ARG-1068 AND TYR-1069
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Cited for: VARIANTS SER-719 AND ARG-858;POSSIBLE INVOLVEMENT IN LUNG CANCER
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Cited for: CHARACTERIZATION OF VARIANTS ALA-709; GLY-709; SER-719; ILE-768; VAL-833; LEU-835; VAL-838; ARG-858 AND GLN-861
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Cited for: VARIANT 30-VAL--ARG-297 DEL;POSSIBLE INVOLVEMENT IN LUNG CANCER
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Cited for: VARIANTS [LARGE SCALE ANALYSIS] LYS-521; ARG-1034 AND VAL-1210